Nicousamide normalizes renovascular hypertension in two-kidney one-clip hypertensive rats

Cardiac output in conscious one-clip, two-kidney renovascular hypertensive rats.

Cardiac output and arterial pressure in the conscious state were observed in one-clip, two-kidney renovascular hypertensive rats with a chronically implanted electromagnetic flow probe and an arterial cannula. Normal Wistar rats were used as controls. At rest, cardiac output per body weight did not show any difference between hypertensive rats and normal controls. This kind of experimental hype...

Impaired renorenal reflexes in two-kidney, one clip hypertensive rats.

In normotensive rats, stimulation of renal mechanoreceptors by an increase in ureteral pressure results in a contralateral inhibitory renorenal reflex response with contralateral natriuresis. Similar effects are produced by stimulation of renal chemoreceptors by renal pelvic perfusion with 0.9 M NaCl. However, in spontaneously hypertensive rats the renorenal reflex responses to renal mechanorec...

Two-kidney, two clip renovascular hypertensive rats can be used as stroke-prone rats.

BACKGROUND AND PURPOSE The cerebrovascular lesions in stroke-prone spontaneously hypertensive rats are not only dependent on high blood pressure but partly related to pressure-independent genetic factors. The aim of the present study was to observe whether spontaneous stroke occurred in renovascular hypertensive rats without a genetic deficiency. METHODS The 1-kidney, 1 clip (1k1c); 2-kidney,...

Dietary potassium and the development of hypertension in two-kidney, one clip Goldblatt hypertensive rats.

Effect of clonidine on blood pressure in chronic one-kidney, one-clip and two-kidney, one-clip hypertensive rats.

Oral administration of clonidine lowered the high blood pressure in two-kidney, one-clip hypertensive rats in chronic stage (three to four months), but not in one-kidney, one-clip hypertensive rats. This reduction of blood pressure was well correlated with decrease in plasma renin concentration, but not with decrease in urinary noradrenaline excretion. These results suggest that the reduction o...